Bariatric surgery in a pill takes a step forward - LA Times - http://www.latimes.com/science...
"It's more of a glimmer of hope on the horizon than it is an actual drug right now. But an Indiana University lab has synthesized and fused a trio of gut hormones into a single agent and shown that obese rodents treated with the resulting molecule experience dramatic weight loss and a reversal of obesity-related ills such as Type 2 diabetes and fatty liver disease. Reporting their latest findings this week in the journal Nature Medicine, the authors of the new study described a cascade of synergistic effects in lab animals in response to the three-hormone agent the researchers devised. The researchers likened the results in lab animals to the subtle and far-reaching changes brought about in human patients following bariatric surgery, who not only experience weight loss in response to gastric bypass surgery, but often an abrupt reversal of Type 2 diabetes, high blood pressure, inflammation and worrisome cholesterol readings." - Steve C, Team Marina
I'll be dead by the time this comes out - "They engineered a single new peptide by integrating three gastrointestinal hormones at the molecular level (glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, and glucagon receptors). Those act on three key hormone receptors that govern metabolism and digestion, nudging them to work cooperatively to support weight loss, enhance glycemic control and reverse the accumulation of damaging fat in the liver." - Todd Hoff