Tweetie for desktop and Twitter (what used to be Tweetie 2) for my iPhone. I like it. A lot. I do wish I could block people from the client. I have to use the website to do that, AFAIK. - Derrick

I discovered you can block now, D, it's just buried. if you go to the person's profile in the client, way down at the bottom under "More" there's a Block Options section. I just found it the other day. it's my preferred client too. :) - holly #ravingfangirl

I use Seesmic Desktop at home and Tweetdeck at work. I like Seesmic better overall, but I like Tweetdeck's notifications. they're both good. and I want to play with Tweetdeck's global filters, which I haven't messed around with yet. - holly #ravingfangirl

Hootsuite on mobile and desktop. I like the flexibility of a web-based client over a resource-hogging AIR app. Hootsuite pretty much offers any feature you could think of in a Twitter client. - Rahsheen

On my EVO I use Seesmic. It's probably the best, most full Twitter client I've ever used. On the iPod I use TwitBird and Twitterific. They're good, but not as robust as Seesmic. I use the Xbox Twitter client occasionally. On my desktop, I mostly use T.witterGadget. It's okay. There's a lot of room for improvement. I also still use Twhirl and DestroyTwitter, but rarely. And then, of course, FriendFeed. - Anika

oh, Twhirl. I *loved* Twhirl. I keep thinking about going back to it. - holly #ravingfangirl

It's not a reliable as it used to be. :( I only open it when I want to watch while doing something else on my computer. - Anika