Rare codons are enriched at gene start in many genomes. Genome analysis and experimental testing show that this enrichment evolved to keep the ribosome binding site free from stable mRNA structures, in order to facilitate efficient translation initiation.
- Abhishek Tiwari
This study presents the first global protein interaction network for all 11 human HDACs in T cells and an integrative mass spectrometry approach for profiling relative interaction stability within isolated protein complexes.
- Abhishek Tiwari
The effect of negative feedback on global and local sources of uncertainty is studied with synthetic circuits stably integrated in human cells. Negative feedback is shown to be the most efficient way to mitigate the effects of global fluctuations by introducing a single additional regulatory link.
- Abhishek Tiwari
Quantitative phosphoproteomics was used to measure the dynamic changes in phosphorylation of ERK1/2 MAP kinases consensus sequences in epithelial cells and to identify 128 novel candidate substrates involved in a broad spectrum of biological functions.
- Abhishek Tiwari