"Our subjective sensory experiences are regulated by defined brain areas subh visual cortex, auditory cortex,somatosensory cortex, etc., but there doesn't appear to be a "pain cortex" that directly codes our subjective perception of pain. Mano and Seymour, in a review of Woo et al., note the emerging concept that pain might emerge from the coordinated activity of an integrated brain network. Woo et al. provide evidence that distinct brain networks support the subjective changes in pain that result from nociceptive input and self-directed cognitive modulation. Their abstract, followed by a summary graphic from Mano and Seymour:" - Todd Hoff