Neuroskeptic: fMRI Gets Slap in the Face with a Dead Fish - http://neuroskeptic.blogspot.com/2009...
"This is a poster presented by Bennett and colleagues at this year's Human Brain Mapping conference. It's about fMRI scanning on a dead fish, specifically a salmon. They put the salmon in an MRI scanner and "the salmon was shown a series of photographs depicting human individuals in social situations. The salmon was asked to determine what emotion the individual in the photo must have been experiencing." I'd say that this research was justified on comedic grounds alone, but they were also making an important scientific point. The (fish-)bone of contention here is multiple comparisons correction. The "multiple comparisons problem" is simply the fact that if you do a lot of different statistical tests, some of them will, just by chance, give interesting results.... Luckily, during the 1990s, fMRI pioneers developed techniques for dealing with the problem: multiple comparisons correction. The most popular method uses Gaussian Random Field Theory to calculate the probability of falsely "finding" activated areas just by chance, and to keep this acceptably low (details), although there are other alternatives. But not everyone uses multiple comparisons correction. This is where the fish comes in - Bennett et al show that if you don't use it, you can find "neural activation" even in the tiny brain of dead fish." - Shannon Jiménez